Nishkarsha unfolds the story of a bank robbery that takes place in broad daylight in an otherwise peaceful Manipal Center in Bangalore City. The bank employees and customers in the bank at that moment are trapped in a lethal trap with nowhere to run. Ananth Nag, the Commissioner of Police tries various ways to get into the bank but without much luck. B.C.Patil, the kingpin behind the robbery project, threatens to start throwing people down one by one if his demands are not met. Without a choice, Ananth summons a special commando force led by Dr.Vishnuvardhan who aids in the rescue operation.